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It began with a promising cancer drug, the brainchild of a gifted researcher, and grew into an insider trading scandal that ensnared one of America's most successful women. The story of ImClone Systems and its "miracle" cancer drug, Erbitux, is the quintessential business saga of the late 1990s. It's the story of big money and cutting-edgescience, celebrity, greed, and slipshod business practices; the story of biotech hype and hope and every kind of excess.At the center of it all stands a single, enigmatic figure named Sam Waksal. A brilliant, mercurial, and desperate-to-be-liked entrepreneur, Waksal was addicted to the trappings of wealth and fame that accrued to a darling of the stock market and the overheated atmosphere of biotech IPOs. At the height of his stardom, Waksal hobnobbed with Martha Stewart in New York and Carl Icahn in the Hamptons, hosted parties at his fabulous art-filled loft, and was a fixture in the gossip columns. He promised that Erbitux would "change oncology," and would soon be making $1 billion a year.But as Waksal partied late into the night, desperate cancer patients languished, waiting for his drug to come to market. When the FDA withheld approval of Erbitux, the charming scientist who had always stayed just one step ahead of bankruptcy panicked and desperately tried to cash in his stock before the bad news hit Wall Street.Waksal is now in jail, the first of the Enron-era white-collar criminals to be sentenced. Yet his cancer drug has proved more durable than his evanescent profits. Erbitux remains promising, the leading example of a new way to fight cancer, and patients and investors hope it will be available soon.

During the Paris Peace Conference of 1919, while key decisions were debated by the victorious Allied powers, a multitude of smaller nations and colonies held their breath, waiting to see how their fates would be decided. President Woodrow Wilson, in his Fourteen Points, had called for "a free, open-minded, and absolutely impartial adjustment of all colonial claims," giving equal weight would be given to the opinions of the colonized peoples and the colonial powers. Among those nations now paying close attention to Wilson's words and actions were the budding nationalist leaders of four disparate non-Western societies--Egypt, India, China, and Korea. That spring, Wilson's words would help ignite political upheavals in all four of these countries. This book is the first to place the 1919 Revolution in Egypt, the Rowlatt Satyagraha in India, the May Fourth movement in China, and the March First uprising in Korea in the context of a broader "Wilsonian moment" that challenged the existing international order. Using primary source material from America, Europe, and Asia, historian Erez Manela tells the story of how emerging nationalist movements appropriated Wilsonian language and adapted it to their own local culture and politics as they launched into action on the international stage. The rapid disintegration of the Wilsonian promise left a legacy of disillusionment and facilitated the spread of revisionist ideologies and movements in these societies; future leaders of Third World liberation movements--Mao Zedong, Ho Chi Minh, and Jawaharlal Nehru, among others--were profoundly shaped by their experiences at the time. The importance of the Paris Peace Conference and Wilson's influence on international affairs far from the battlefields of Europe cannot be underestimated. Now, for the first time, we can clearly see just how the events played out at Versailles sparked a wave of nationalism that is still resonating globally today.

An invaluable resource that will guide new research on the major groups within the fungal kingdom. Provides illuminating insights into the molecular details of cell-type specification, mating-type switching, pheromone perception and signaling, and cellular and nuclear fusion. Includes chapters on both model and pathogenic fungi, as well as a section that looks forward to what we hope to learn in other fungal lineages. Concludes with a selection of chapters on the implications of sex and studies of experimental evolution in a broader evolutionary context.

During the Paris Peace Conference of 1919, while key decisions were debated by the victorious Allied powers, a multitude of smaller nations and colonies held their breath, waiting to see how their fates would be decided. President Woodrow Wilson, in his Fourteen Points, had called for "a free, open-minded, and absolutely impartial adjustment of all colonial claims," giving equal weight would be given to the opinions of the colonized peoples and the colonial powers. Among those nations now paying close attention to Wilson's words and actions were the budding nationalist leaders of four disparate non-Western societies--Egypt, India, China, and Korea. That spring, Wilson's words would help ignite political upheavals in all four of these countries. This book is the first to place the 1919 Revolution in Egypt, the Rowlatt Satyagraha in India, the May Fourth movement in China, and the March First uprising in Korea in the context of a broader "Wilsonian moment" that challenged the existing international order. Using primary source material from America, Europe, and Asia, historian Erez Manela tells the story of how emerging nationalist movements appropriated Wilsonian language and adapted it to their own local culture and politics as they launched into action on the international stage. The rapid disintegration of the Wilsonian promise left a legacy of disillusionment and facilitated the spread of revisionist ideologies and movements in these societies; future leaders of Third World liberation movements--Mao Zedong, Ho Chi Minh, and Jawaharlal Nehru, among others--were profoundly shaped by their experiences at the time. The importance of the Paris Peace Conference and Wilson's influence on international affairs far from the battlefields of Europe cannot be underestimated. Now, for the first time, we can clearly see just how the events played out at Versailles sparked a wave of nationalism that is still resonating globally today.

Sexual reproduction is a fundamental aspect of life. It is defined by the occurrence of meiosis and the fusion of two gametes of different sexes or mating types. Sex-determination mechanisms are responsible for the sexual fate and development of sexual characteristics in an organism, be it a unicellular alga, a plant, or an animal. In many cases, sex determination is genetic: males and females have different alleles or different genes that specify their sexual morphology. In animals, this is often accompanied by chromosomal differences. In other cases, sex may be determined by environmental (e.g. temperature) or social variables (e.g. the size of an organism relative to other members of its population). Surprisingly, sex-determination mechanisms are not evolutionarily conserved but are bewilderingly diverse and appear to have had rapid turnover rates during evolution. Evolutionary biologists continue to seek a solution to this conundrum. What drives the surprising dynamics of such a fundamental process that always leads to the same outcome: two sex types, male and female? The answer is complex but the ongoing genomic revolution has already greatly increased our knowledge of sex-determination systems and sex chromosomes in recent years. This novel book presents and synthesizes our current understanding, and clearly shows that sex-determination evolution will remain a dynamic field of future research. The Evolution of Sex Determination is an advanced, research level text suitable for graduate students and researchers in genetics, developmental biology, and evolution.

An invaluable resource that will guide new research on the major groups within the fungal kingdom. Provides illuminating insights into the molecular details of cell-type specification, mating-type switching, pheromone perception and signaling, and cellular and nuclear fusion. Includes chapters on both model and pathogenic fungi, as well as a section that looks forward to what we hope to learn in other fungal lineages. Concludes with a selection of chapters on the implications of sex and studies of experimental evolution in a broader evolutionary context.

Sexual reproduction is a fundamental aspect of life. It is defined by the occurrence of meiosis and the fusion of two gametes of different sexes or mating types. Sex-determination mechanisms are responsible for the sexual fate and development of sexual characteristics in an organism, be it a unicellular alga, a plant, or an animal. In many cases, sex determination is genetic: males and females have different alleles or different genes that specify their sexual morphology. In animals, this is often accompanied by chromosomal differences. In other cases, sex may be determined by environmental (e.g. temperature) or social variables (e.g. the size of an organism relative to other members of its population). Surprisingly, sex-determination mechanisms are not evolutionarily conserved but are bewilderingly diverse and appear to have had rapid turnover rates during evolution. Evolutionary biologists continue to seek a solution to this conundrum. What drives the surprising dynamics of such a fundamental process that always leads to the same outcome: two sex types, male and female? The answer is complex but the ongoing genomic revolution has already greatly increased our knowledge of sex-determination systems and sex chromosomes in recent years. This novel book presents and synthesizes our current understanding, and clearly shows that sex-determination evolution will remain a dynamic field of future research. The Evolution of Sex Determination is an advanced, research level text suitable for graduate students and researchers in genetics, developmental biology, and evolution.

Intracellular biochemical pathways control the behavior of immune cells (T cells) in response to changes (cancer) in t he cellular environment. This book examines translational pathways related to the success or failure of the T cell immune system to remove a growing cancer and how the fate of those pathways influence the immunotherapeutic treatment of cancer.

Offers an interpretation of neoliberal ideology as a political theology of chance that both justifies and dissembles risk-laden market processes as obscure divination tools used both to determine fate and fortune and yet to deny that such determination is taking place by any accountable authority.

A relentless horde of renegade robots has plunged the fate of Xanth in dire peril. All that stands between the enchanted land and destruction is a most unlikely hero, a moody, mild-mannered Goblin named Goody, who must summon all of his courage and determination to overcome this abominable army of automatons.Brimming with heart-stopping adventure and heart-warming delight, overflowing with wicked wit and wanton wordplay, Pet Peeve is Piers Anthony in rare form, an exceptional new chapter in the continuing chronicles of Xanth.

Offers an interpretation of neoliberal ideology as a political theology of chance that both justifies and dissembles risk-laden market processes as obscure divination tools used both to determine fate and fortune and yet to deny that such determination is taking place by any accountable authority.

CAMILLA WALTERS finds herself on the outside of ALEXI CARRERO's world after he sets her loose. Following a dramatic end to their roller coaster relationship and is trying to start over again.She's healing, wounded and low, but with determination to get back on her feet as fast as she can.Fate takes a turn one awful night, and leads her straight back to the door of the people she swore never to rely on again, pulling her back into the world she had run away from. The Carrero world and the man who broke her.Like magnets drawn to one another it is obvious their story is not over yet.Will Camilla ever be able to forget the past and what he did to make her hate him? Can she ever trust Alexi Carrero?Contains some mature, adult content, and language.* * * * * *Book 8 is the second in the Carrero Contract Trilogy in The Carrero Series.There are now accompanying bonus books for every trio in the series - Alexi's, POV book will follow book 9 , the books can be found on my Amazon Authors Page

Base on true events, this brilliantly rendered novel recounts a dramatic tale of survival, and a woman’s determination to triumph over a harrowing fate.In 1908, Mexican captain Ramón Arnaud and his young bride, Alicia, set sail for Clipperton, a tiny Pacific atoll once dubbed "Isle of Passion" by Spanish explorers. Accompanied by eleven soldiers and their families, the captain is under orders to defend the isolated but strategically well situated island against an improbable French invasion. With its treacherous coral reef and stagnant lagoon, Clipperton is a dire, forbidding place for the new inhabitants. Rigid military order soon gives way to more informal island living, but under Ramón's guidance and inspired by Alicia's determination the group manages to create a viable community. There are a food store, pharmacy, lighthouse, even dinner parties. But then, amid political upheaval at home and the first rumblings of World War I, the Clipperton residents are forgotten. The supply ship slated to come every two months comes every third, then sixth, then not at all. Left to the mercies of nature and each other, they fall victim one by one to scurvy, hunger, despair, rivalry, lust and, ultimately, violence.Alicia, steadfast and resourceful, becomes a beacon of strength for the remaining castaways, whose collective survival will depend upon her courage and cunning. Drawing on historical records, archives and interviews, prize-winning novelist Laura Restrepo has reimagined the incredible true story of love and war, hardship and endurance, adventure and hope on the Isle of Passion. In prose that is lush, evocative and utterly beguiling, she brings to life a bizarre, moving episode in Mexican history and its extraordinary, unforgettable heroine.

This book consists of a series of statements from men and women dating between 1501 to 1559. These statements illustrate the ideas, beliefs, and somtimes the fates, of the people who had come to share a profound discontent with the church as it then existed and a positive determination to change it. Writings include: Erasmus and Hutten the humanists, Luther and Melanchthon, Zwingli, Sattler the Anabaptist, Servetus the Unitarian, Calvin the theologian and lawgiver, and the English reformers, a special breed -- from the rabble-rousing Fish to Cromwell the administrator, Starkey the moderate, the King and the Archbishop of Canterbury. Spitz provides historical and theological context for each document and a reading list for further exploration.

By time you read this sentence, everything changed. The earth moved. Your body made new cells. Clouds shifted. Birth and death occurred. Yet something remains the same. A constant force prevails. Securing our relationship with this force takes daily determination. In the process, we look less to quick fixes and more to spirituality to discover this force. Dialogue in 21st Century Science and Health reveals a system that guides the mind, soothes the soul, and feeds the body. It discusses divine science. Divine science can pierce the thrilling, mind-boggling, nauseating, complex, and changing world to reveal the constant force of truth and love.

The cold steel slam of a cell door. The soul-crushing fate of a life in prison with no possibility of parole for a crime you didn't commit. Such were the prospects facing Johnny Bragg, a humble musician from rural Tennessee who led a life that reads like a novel. Johnny and his fellow inmates in the 1950's-era R&B music group the Prisonaires had four strikes against them. They were poor, uneducated, imprisoned, and Black. They were also largely innocent of their crimes. Their gut-wrenching story is one of courage in the face of impossible odds, and salvation amidst the harsh realities of racial injustice and prison brutality. Championed by then Tennessee governor Frank Clement as an example of the possibility of prison reform, and asked to sing at the Governor's Mansion, the Prisonaires were more than just pioneers who built the foundation of modern R&B. Behind the soulful tenor of their leader, Johnny Bragg, the group was living proof that anyone can survive and overcome nightmarish adversity. Just Walkin' in the Rain is a book for all audiences who want to delve into one of the most inspiring chapters in musical history. You'll read how Elvis was influenced by the group's amazing sound. You may be stunned to discover that Johnny Bragg wrote the legendary song "Just Walkin' in the Rain" and the Hank Williams classic, "Your Cheatin' Heart."

In the Forgotten Realms (R) Endless Quest (R) books, you don't just read a fantastic tale set in the most popular Dungeons & Dragons (R) world of all time. You become the hero! Answer the call to adventure, and choose your own fate! You awaken in an underground cell, stripped of your armour and your sword. Your fellow prisoners inform you that you're trapped in the Underdark, soon to be taken to the great drow city of Menzoberranzan and sold off as a slave! But word is that demons are stirring in the underworld's depths, and maybe you can use that to break free...

Kinsale, Ireland: Christmas Eve, 1601As thunder crashes and lightning rakes the sky, three very different commanders line up for a battle that will decide the fate of a nation.General Juan del Águila has been sprung from a prison cell to command the last great Spanish Armada. Its mission: to seize a bridgehead in Queen Elizabeth's territory and hold it.Facing him is Charles Blount, a brilliant English strategist whose career is also under a cloud. His affair with a married woman edged him into a treasonous conspiracy – and brought him to within a hair’s breadth of the gallows.Meanwhile, Irish insurgent Hugh O’Neill knows that this is his final chance to drive the English out of Ireland.For each man, this is the last throw of the dice. Tomorrow they will be either heroes – or has-beens.These colourful commanders come alive in this true-life story of courage and endurance, of bitterness and betrayal, and of intrigue at the highest levels in the courts of England and Spain.Praise for The Stolen Village'...a harrowing tale that sheds light on the little-known trade in white slaves ... a fascinating exploration of a forgotten chapter of British and European history' Giles Milton - BBC History Magazine

Welcome to the Forgotten Realms Endless Quest books, where you don’t just read a fantastic tale. You become the hero — and choose your own fate.You awaken in an underground cell, stripped of your armor and your sword. Your fellow prisoners inform you that you’re trapped in the Underdark, soon to be taken to the great drowcity of Menzoberranzan and sold off as a slave. But word is that demons are stirring in the underworld’s depth. Perhaps you can use that to break free, fighter.

Intended for undergraduate and graduate courses in plant development, this book explains how the cells of a plant acquire and maintain their specific fates. Plant development is a continuous process occurring throughout the life cycle, with similar regulatory mechanisms acting at different stages and in different parts of the plant. Rather than focussing on the life cycle, the book is structured around these underlying mechanisms, using case studies to provide students with a framework to understand the many factors, both environmental and endogenous, that combine to regulate development and generate the enormous diversity of plant forms. New approach to the study of plant development and a refreshing look at this fast-moving area. Authors focus their discussion on the basic mechanisms which underpin plant development, tackling the fundamental question of how a single cell becomes a complex flowering plant from a cellular perspective. An up-to-date, modern text in plant development for advanced level undergraduates and postgraduates in plant science. Thought-provoking treatment of a difficult subject, the text will satisfy the needs of advanced level undergraduates and postgraduates in plant science. Experimental case studies throughout. The artwork from the book is available at www.blackwellpublishing.com/leyser